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Compared with mouse thymocytes, mouse ES cells contain greater ranges of complete genomic H3K4me3 and have higher H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 46 In settlement with this, global decreases in H3K4me3 levels happen throughout retinoic acid (RA)-induced differentiation of mouse ES cells 47 As well as, there are dynamic modifications in H3K4me3 profiles at particular sets of genes during ES cell differentiation.
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