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+For instance, human SET7/9 has lately been reported to methylate Lys189 within the common transcription issue TAF10, leading to an increased affinity for RNA polymerase II and transcriptional activation of sure TAF10-dependent genes 37 SET7/9 has also been reported to methylate p53, increasing the soundness of this quick lived tumor-suppressor protein 38 These observations recommend that we must always not narrowly outline the SET-domain proteins as histone lysine methyltransferases but as a substitute call them protein lysine methyltransferases.
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