diff --git a/.vpython b/.vpython
deleted file mode 100644
index c9df48062..000000000
--- a/.vpython
+++ /dev/null
@@ -1,76 +0,0 @@
-python_version: "2.7"
-
-# The default set of platforms vpython checks for does not yet include mac-arm64.
-# Setting `verify_pep425_tag` to the list of platforms we explicitly must support
-# allows us to ensure that vpython specs stay mac-arm64-friendly
-verify_pep425_tag: [
-    {python: "cp27", abi: "cp27mu", platform: "manylinux1_x86_64"},
-    {python: "cp27", abi: "cp27mu", platform: "linux_arm64"},
-    {python: "cp27", abi: "cp27mu", platform: "linux_armv6l"},
-
-    {python: "cp27", abi: "cp27m", platform: "macosx_10_10_intel"},
-    {python: "cp27", abi: "cp27m", platform: "macosx_11_0_arm64"},
-
-    {python: "cp27", abi: "cp27m", platform: "win32"},
-    {python: "cp27", abi: "cp27m", platform: "win_amd64"}
-]
-
-# Used by:
-#   auth.py
-#   gerrit_util.py
-#   git_cl.py
-#   my_activity.py
-#   TODO(crbug.com/1002153): Add ninjalog_uploader.py
-wheel: <
-  name: "infra/python/wheels/httplib2-py2_py3"
-  version: "version:0.10.3"
->
-
-# Used by:
-#    presubmit_support.py
-wheel: <
-  name: "infra/python/wheels/requests-py2_py3"
-  version: "version:2.13.0"
->
-
-# Used by:
-#   my_activity.py
-wheel: <
-  name: "infra/python/wheels/python-dateutil-py2_py3"
-  version: "version:2.7.3"
->
-wheel: <
-  name: "infra/python/wheels/six-py2_py3"
-  version: "version:1.10.0"
->
-
-# Used by:
-#   tests/auth_test.py
-#   tests/detect_host_arch_test.py
-#   tests/gclient_scm_test.py
-#   tests/gclient_test.py
-#   tests/gclient_utils_test.py
-#   tests/gerrit_util_test.py
-#   tests/git_cl_test.py
-#   tests/git_footers_test.py
-#   tests/metrics_test.py
-#   tests/presubmit_unittest.py
-#   tests/scm_unittest.py
-#   tests/subprocess2_test.py
-#   tests/watchlists_unittest.py
-wheel: <
-  name: "infra/python/wheels/mock-py2_py3"
-  version: "version:2.0.0"
->
-wheel <
-  name: "infra/python/wheels/funcsigs-py2_py3"
-  version: "version:1.0.2"
->
-wheel: <
-  name: "infra/python/wheels/pbr-py2_py3"
-  version: "version:3.0.0"
->
-wheel: <
-  name: "infra/python/wheels/six-py2_py3"
-  version: "version:1.10.0"
->
diff --git a/cipd_manifest.txt b/cipd_manifest.txt
index 7ce6b19fa..90407d23c 100644
--- a/cipd_manifest.txt
+++ b/cipd_manifest.txt
@@ -36,7 +36,7 @@ $VerifiedPlatform linux-armv6l linux-mips64 linux-mips64le linux-mipsle
 $VerifiedPlatform windows-arm64
 
 # vpython.
-infra/tools/luci/vpython/${platform} git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
+infra/tools/luci/vpython3/${platform} git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
 
 # LUCI editor
 infra/tools/luci/led/${platform} git_revision:2d4970c1db4df5cf1cc11355326729c3f8e37407
diff --git a/cipd_manifest.versions b/cipd_manifest.versions
index 243757f42..5d752261a 100644
--- a/cipd_manifest.versions
+++ b/cipd_manifest.versions
@@ -385,65 +385,65 @@ infra/tools/luci/lucicfg/windows-arm64
 	git_revision:9827af897b3078e2dd69c9c058c2e76ec8c26dc9
 	OUmTepSE2mTonD-dNRs2MaXa1ZGxtCWbzzdk3zvFSk0C
 
-infra/tools/luci/vpython/linux-386
+infra/tools/luci/vpython3/linux-386
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	5XCEuCpKo96l0GAWvnWB4Uog0AeIrrLBOdf020hgygQC
+	LSv2jnsr-7v4iNnqY-2lMmBB6ZiXyNYY8lURAhZUH0AC
 
-infra/tools/luci/vpython/linux-amd64
+infra/tools/luci/vpython3/linux-amd64
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	gFBKqINUZLiOlRuph3Mo60hBjCxH7b2bX_k1YNMsnzMC
+	ovQwRDoJhNqOV-iyKA8FjywcIA-Gd6vaxMKIKovJ2mAC
 
-infra/tools/luci/vpython/linux-arm64
+infra/tools/luci/vpython3/linux-arm64
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	KHuy2LO9GIrcL0Ke1cV_esAKwRjN4C5OyQ6nudgGphwC
+	WsoR8xIDVlJzgQHaamyGOPpb22YlX3sbyij2DvjOBQoC
 
-infra/tools/luci/vpython/linux-armv6l
+infra/tools/luci/vpython3/linux-armv6l
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	mQ8bSGK04iiCYuHiMT2s1OUSosLqm1CRWaH9u9VczFQC
+	99in3dAtvzqeHwIwF02MAEfiB-G9iWO53v342Lq4oFYC
 
-infra/tools/luci/vpython/linux-mips64
+infra/tools/luci/vpython3/linux-mips64
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	w6cB-w0SMWla2sYWa3SnjymPJevF43BJ1Rluaec3HXMC
+	HpevxOS1AcbxWanSSLHQzhZ-sSPUSqnirLmpdeSwsooC
 
-infra/tools/luci/vpython/linux-mips64le
+infra/tools/luci/vpython3/linux-mips64le
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	RazW56TFJk8EZAzTau1qppjABIoaryE16gjkTo8ljUMC
+	exAC5qVd221Hlr3pcBqiERuVLMZ0vA1etWI1isTJVNsC
 
-infra/tools/luci/vpython/linux-mipsle
+infra/tools/luci/vpython3/linux-mipsle
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	QMZQG8XxzdH11d8YFP2TRPzRBOCV9we5FaM63oI3ZDoC
+	63XWHf_tz8JZXTP-XZkz5FejfvsIHJeN1C4wmUzyu4AC
 
-infra/tools/luci/vpython/linux-ppc64
+infra/tools/luci/vpython3/linux-ppc64
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	c7cyFyzoPItwI86hvB7ACZ16jtBV-v1Pq5gQk_teq5cC
+	4TDNfR1iO2d8Mpebe-ionhGhttE8ynOLQXtYQ20yoSMC
 
-infra/tools/luci/vpython/linux-ppc64le
+infra/tools/luci/vpython3/linux-ppc64le
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	HWdIhJ0mDYFzpyIZqYGM9NgBtV7dTzoCUMaPEA9gvy4C
+	Pk7m7LyigjgNX0iBqflIUan5eDdRRqr_3imS2i94tmsC
 
-infra/tools/luci/vpython/linux-riscv64
+infra/tools/luci/vpython3/linux-riscv64
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	e9qGcT3OxmsubATYdd-fxaxc3sEmdc-GKgYWS_twFnMC
+	dLLb1rYCVIWgsPoyfT5REVspsSqySTBTX5ZK2vFrc_0C
 
-infra/tools/luci/vpython/linux-s390x
+infra/tools/luci/vpython3/linux-s390x
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	q3latzYdJnhbPnze0sij4bLShocNICeNGYJ7FR1272kC
+	VDNw9r3hA4B2PCki0MtNvIzLfgr0WkT2O8G3g7zXelgC
 
-infra/tools/luci/vpython/mac-amd64
+infra/tools/luci/vpython3/mac-amd64
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	mlSOx-jy8Ntrh98cOZTcgQN6RrWXm5tBxKWDxhxrNVwC
+	qUCWlve2bacyVNcoN-S21GKpkdPRxP2kZP4ygP6gMLoC
 
-infra/tools/luci/vpython/mac-arm64
+infra/tools/luci/vpython3/mac-arm64
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	DgWwOCjBqH9Nc2LRLFbTZ9JTwHlwcwT7esanwSCbBAAC
+	YPPISxeZPIZRSLolAuJo8SqomP4bWT2yw-jWdcy8Y_wC
 
-infra/tools/luci/vpython/windows-amd64
+infra/tools/luci/vpython3/windows-amd64
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	oluqkEWDxYtHzDCkIUl9840g6Ix8qBncMVmtu8yOplkC
+	jUkfILL7JKj_4n84BaPvMBOkok-Iu9_hgMFLkEif50QC
 
-infra/tools/luci/vpython/windows-arm64
+infra/tools/luci/vpython3/windows-arm64
 	git_revision:0c1a41fa62950eedcaaee58ba7268d3813871e3f
-	yTXSPAek0nBC9yzj06d7DtQZIbNV9EKCEakVxSmHAIYC
+	EZ2JiY1_lNSKS-Lb_z9Iev_mKkJFekhQC0h2-DY8DwEC
 
 infra/tools/mac_toolchain/mac-amd64
 	git_revision:05fe195bf77656743f3daa99d463a794260b429b
diff --git a/gn.py b/gn.py
index 296042ed4..a56bc97b4 100755
--- a/gn.py
+++ b/gn.py
@@ -55,7 +55,7 @@ def main(args):
     # Invocations of `python` from GN should never inherit the gn.py's own
     # VirtualEnv. This also helps to ensure that generated ninja files do not
     # reference python.exe from the VirtualEnv generated from depot_tools' own
-    # .vpython file (or lack thereof), but instead reference the default python
+    # .vpython3 file (or lack thereof), but instead reference the default python
     # from the PATH.
     PruneVirtualEnv()
 
diff --git a/presubmit_canned_checks.py b/presubmit_canned_checks.py
index f3cc6f6ab..e321a108a 100644
--- a/presubmit_canned_checks.py
+++ b/presubmit_canned_checks.py
@@ -1355,8 +1355,8 @@ def GetPylint(input_api,
         kwargs = {'env': env}
         if input_api.platform == 'win32':
             # On Windows, scripts on the current directory take precedence over
-            # PATH. When `pylint.bat` calls `vpython`, it will execute the
-            # `vpython` of the depot_tools under test instead of the one in the
+            # PATH. When `pylint.bat` calls `vpython3`, it will execute the
+            # `vpython3` of the depot_tools under test instead of the one in the
             # bot. As a workaround, we run the tests from the parent directory
             # instead.
             cwd = input_api.change.RepositoryRoot()
@@ -2079,8 +2079,8 @@ def CheckVPythonSpec(input_api, output_api, file_filter=None):
         output_api: Bag of output related interfaces.
         file_filter: Custom function that takes a path (relative to client root) and
             returns boolean, which is used to filter files for which to apply the
-            verification to. Defaults to any path ending with .vpython, which captures
-            both global .vpython and <script>.vpython files.
+            verification to. Defaults to any path ending with .vpython(3), which captures
+            both global .vpython(3) and <script>.vpython(3) files.
 
     Returns:
         A list of input_api.Command objects containing verification commands.
diff --git a/presubmit_support.py b/presubmit_support.py
index 25970f173..10480854d 100755
--- a/presubmit_support.py
+++ b/presubmit_support.py
@@ -195,7 +195,7 @@ class ThreadPool(object):
 
         # On Windows, scripts on the current directory take precedence over
         # PATH, so that when testing depot_tools on Windows, calling
-        # `vpython.bat` will execute the copy of vpython of the depot_tools
+        # `vpython3.bat` will execute the copy of vpython of the depot_tools
         # under test instead of the one in the bot. As a workaround, we run the
         # tests from the parent directory instead.
         if (cmd[0] == vpython and 'cwd' in test.kwargs
diff --git a/vpython b/vpython
deleted file mode 100755
index 55fd4aadc..000000000
--- a/vpython
+++ /dev/null
@@ -1,56 +0,0 @@
-#!/usr/bin/env bash
-
-# Copyright 2018 The Chromium Authors. All rights reserved.
-# Use of this source code is governed by a BSD-style license that can be
-# found in the LICENSE file.
-
-# See revert instructions in cipd_manifest.txt
-
-if [[ $VPYTHON_BYPASS == "manually managed python not supported by chrome operations" ]]
-then
-  NEWARGS=()
-  while [[ $# -gt 0 ]]
-  do
-    case "$1" in
-      -vpython-tool*) # these tools all do something vpython related and quit
-        exit 0
-        ;;
-      -vpython*=*) # delete any vpython-specific flag (w/ attached argument)
-        shift
-        ;;
-      -vpython*) # delete any vpython-specific flag (w/ separate argument)
-        shift
-        shift
-        ;;
-      --)     # stop parsing
-        NEWARGS+=( "$@" )
-        break
-        ;;
-      *)      # regular arg
-        NEWARGS+=( "$1" )
-        shift
-        ;;
-    esac
-  done
-  exec "python" "${NEWARGS[@]}"
-fi
-
-# Export for other depot_tools scripts to re-use.
-export DEPOT_TOOLS_DIR="${DEPOT_TOOLS_DIR:-$(dirname "$0")}"
-export DEPOT_TOOLS_UNAME_S="${DEPOT_TOOLS_UNAME_S:-$(uname -s | tr '[:upper:]' '[:lower:]')}"
-
-source "${DEPOT_TOOLS_DIR}/cipd_bin_setup.sh"
-cipd_bin_setup &> /dev/null
-
-# Don't pass this to the Python script as it might turn around and run commands
-# in other depot_tools dirs.
-base_dir="${DEPOT_TOOLS_DIR}"
-unset DEPOT_TOOLS_DIR
-case "${DEPOT_TOOLS_UNAME_S}" in
-mingw*|cygwin*)
-  cmd.exe //c $0.bat "$@"
-  ;;
-*)
-  exec "${base_dir}/.cipd_bin/vpython" "$@"
-  ;;
-esac
diff --git a/vpython.bat b/vpython.bat
deleted file mode 100644
index e5ef643c0..000000000
--- a/vpython.bat
+++ /dev/null
@@ -1,9 +0,0 @@
-@echo off
-:: Copyright 2017 The Chromium Authors. All rights reserved.
-:: Use of this source code is governed by a BSD-style license that can be
-:: found in the LICENSE file.
-
-:: See revert instructions in cipd_manifest.txt
-
-call "%~dp0\cipd_bin_setup.bat" > nul 2>&1
-"%~dp0\.cipd_bin\vpython.exe" %*