diff --git a/gsutil.py b/gsutil.py
index eb339bc41..d57cafb94 100755
--- a/gsutil.py
+++ b/gsutil.py
@@ -29,9 +29,6 @@ DEFAULT_BIN_DIR = os.path.join(THIS_DIR, 'external_bin', 'gsutil')
 DEFAULT_FALLBACK_GSUTIL = os.path.join(
     THIS_DIR, 'third_party', 'gsutil', 'gsutil')
 
-IS_WINDOWS = os.name == 'nt'
-
-
 class InvalidGsutilError(Exception):
   pass
 
@@ -129,17 +126,8 @@ def run_gsutil(force_version, fallback, target, args, clean=False):
   else:
     gsutil_bin = fallback
   disable_update = ['-o', 'GSUtil:software_update_check_period=0']
-
-  # Run "gsutil" through "vpython". We need to do this because on GCE instances,
-  # expectations are made about Python having access to "google-compute-engine"
-  # and "boto" packages that are not met with non-system Python (e.g., bundles).
-  cmd = [
-      'vpython',
-      '-vpython-spec', os.path.join(THIS_DIR, 'gsutil.vpython'),
-      '--',
-      gsutil_bin
-  ] + disable_update + args
-  return subprocess.call(cmd, shell=IS_WINDOWS)
+  cmd = [sys.executable, gsutil_bin] + disable_update + args
+  return subprocess.call(cmd)
 
 
 def parse_args():
diff --git a/gsutil.vpython b/gsutil.vpython
deleted file mode 100644
index ad7207dcd..000000000
--- a/gsutil.vpython
+++ /dev/null
@@ -1,21 +0,0 @@
-# vpython VirtualEnv protobuf for "gsutil".
-#
-# See:
-# https://chromium.googlesource.com/infra/luci/luci-go/+/master/vpython/api/vpython/spec.proto
-#
-# This is a "vpython" VirtualEnv specification applied to invocations of "gsutil"
-# by the bootstrap wrapper, "gsutil.py". It ensures that any Python distribution
-# has the expected Python packages installed.
-#
-# This is specifically relevant on Google Compute Engine invocations of
-# "gsutil", where a stock system-deployed file in "/etc/" explicitly specifies
-# that the "google_compute_engine" and "boto" Python packages are available.
-
-wheel <
-  name: "infra/python/wheels/google_compute_engine-py2_py3"
-  version: "version:2.3.7"
->
-wheel <
-  name: "infra/python/wheels/boto-py2_py3"
-  version: "version:2.47.0"
->